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KMID : 0363120210340010035
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Korean Journal of Pain
2021 Volume.34 No. 1 p.35 ~ p.46
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Antinociceptive effects of oleuropein in experimental models of neuropathic pain in male rats
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Chen Huayong
Ma Dandan
Zhang Huapeng
Tang Yanhong
Wang Jun
Li Renhu
Wen Wen
Zhang Yi
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Abstract
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Background: The present investigation explored the therapeutic actions of oleuropein along with the possible signaling pathway involved in attenuating neuropathic pain in chronic constriction injury (CCI) and vincristine-induced neuropathic pain in male rats.
Methods: Four loose ligatures were placed around the sciatic nerve to induce CCI, and vincristine (50 μg/kg) was injected for 10 days to develop neuropathic pain. The development of cold allodynia, mechanical allodynia, and mechanical hyperalgesia was assessed using different pain-related behavioral tests. The levels of H2S, cystathionine-γ-lyase (CSE), cystathionine-β-synthase (CBS), orexin, and nuclear factor erythroid-2-related factor 2 (Nrf2) were measured in the sciatic nerve.
Results: Treatment with oleuropein for 14 days led to significant amelioration of behavioral manifestations of neuropathic pain in two pain models. Moreover, oleuropein restored both CCI and vincristine-induced decreases in H2S, CSE, CBS, orexin, and Nrf2 levels. Co-administration of suvorexant, an orexin receptor antagonist, significantly counteracted the pain-attenuating actions of oleuropein and Nrf2 levels without modulating H2S, CSE and CBS.
Conclusions: Oleuropein has therapeutic potential to attenuate the pain manifestations in CCI and vincristine-induced neuropathic pain, possibly by restoring the CSE, CBS, and H2S, which may subsequently increase the expression of orexin and Nrf2 to ameliorate behavioral manifestations of pain.
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KEYWORD
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Hydrogen Sulfide, Hyperalgesia, Neuralgia, Neuropeptides, NF-E2-Related Factor 2, Nociception, Orexins, Orexin Receptor Antagonists, Polyphenols, Vincristine
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